Skip to main content
Homepage GET RELIEF RESPONSIBLY®

Learn the Differences Between Pain Relievers

Not all over-the–counter (OTC) pain medications are appropriate for everyone. There are 2 main types—and understanding the differences between them could matter to your health.

There may seem to be dozens of choices on store shelves, but there really are only 2 main types of over-the-counter (OTC) oral pain relievers:  acetaminophen  and  NSAIDs (nonsteroidal anti-inflammatory drugs) . Examples of oral NSAIDs include: ibuprofen, naproxen (sodium) and acetylsalicylic acid. They may all relieve the same symptoms, but they work differently in your body and have different active ingredients, warnings, and dosing directions. One type may be more appropriate for you, based on your age, health conditions, and other medicines you currently take. It’s important to understand pain reliever differences so that you can help select an appropriate choice for you. When in doubt, check with a healthcare professional.


2 main types

Medicinal ingredient

Acetaminophen

Acetaminophen
for example: TYLENOL®

NSAIDs
nonsteroidal anti-inflammatory drugs

Ibuprofen
for example: MOTRIN®, Advil®

Naproxen Sodium
for example: Aleve®, MOTRIMAXTM 12 HOUR

Acetylsalicylic Acid
for example: Aspirin®

Diclofenac*
for example: Voltaren Emulgel®
*
applied topically

What to know: Acetaminophen and NSAIDs may treat the same symptoms, but they work differently in your body, and they have different warnings and dosing directions. One type may be more appropriate for you than the other.

The third-party trademarks used herein are trademarks of their respective owners.

Related Articles

Compare Pain Relievers

OTC pain reliever differences could matter to your health

How you choose OTC pain medications and how you use them are important.

OTC Pain Relievers for You

Which OTC pain reliever may be appropriate for you?

It may depend on your age, health conditions and other medications you may be currently taking.

How to Read Medicine Labels

Medicine labels matter to your health

What the warnings, directions, and other label facts tell you.